Article List
- Polyethylene glycol PEGWhile retaining the intrinsic biological activity of natural proteins, PEG ylated proteins can effectively overcome some of the shortcomings of protein drugs in clinical applications, such as increasing plasma half-life, enhancing bioavailability, reducing protein immunogenicity, and improving drug efficacy. And safety, etc. In order to couple PEG to proteins under milder reaction conditions, PEG is activated, and the activated PEG is coupled to an amino group, a thiol group or a carboxyl group on the protein molecule. Many organic small molecule drugs have gradually adopted PEG modification technology, and some progress has been made. The modification of small molecule drugs by polyethylene glycol can transfer many of its excellent properties to the conjugate, so that the polymer Has excellent biocompatibility.Product & Technology November 20, 2018
- The use of Polyethylene glycol modificationPolyethylene glycol (PEG) is a pH-neutral, non-toxic, water-soluble hydrophilic polymer with repeating units of oxyethylene and terminal groups of two hydroxyl groups, linear or branched. Chain structure. PEG polymer is the polymer with the lowest level of protein and cell absorption in polymers. Due to its non-toxic PEG and good biocompatibility, PEG has been approved by the FDA as an injectable pharmaceutical polymer. Modification is the process of chemically coupling activated PEG to a drug, ie, PEGylation. Polyethylene glycol (PEG) was first used for drug modification. In 1977, Abuchowsk et al. used PEG to modify bovine serum albumin. It was found that it can effectively change its immunological properties. The researchers then used PEG to modify the anticancer drug asparaginase and applied it to the clinic.
- Polyethylene glycol in medical applicationsPolyethylene glycol (PEG) is a widely used polyether polymer compound. Polyethylene glycol (PEG) can be used in many fields such as medicine, health, food, and chemical industry. Polyethylene glycol (PEG) can be dissolved in water and many solvents, and the polymer has excellent biocompatibility, can be dissolved in the tissue fluid in the body, and can be quickly eliminated by the body without any toxic side effects.
- Current status of concrete low temperature early strength agentThe hydration hardening property of cement determines the early strength of concrete. Under standard conditions, the strength can only reach 20%~30% of the design strength and the strength of 3d reaches 40%. Under the low temperature condition in winter, the strength development rate will become Lower. Concrete early strength agent is an admixture that accelerates the early strength development of concrete, and its content generally does not exceed 5% of the mass of cement. At room temperature (20±3) °C, the concrete with early strength agent can reach the demoulding strength for 10h, usually up to 50% of the design strength at 1d, and the strength of the reference concrete for 28d at 3d.
- Comparison of properties of alcohol amine cement grinding aidsThe cement industry is a high-energy-consuming industry, and the energy consumption in the cement grinding process accounts for a large proportion in the whole production process, of which electricity consumption accounts for 60%-70%, and its energy utilization rate is extremely low. About 97% of the energy consumed in the grinding process becomes a waste of heat, and only a small part of the energy increases the surface area of the material, in order to reduce energy consumption, save energy, and improve grinding efficiency.Product & Technology November 16, 2018
- Effect of TIPA on cement grinding and hydration performanceTIPA is a rectification separation of ammonia and propylene oxide after addition reaction. Triisopropanolamine can be widely used in daily chemical, fine chemical, petrochemical, etc., and is an important amine compound. TIPA is the core material for cement grinding aids, and triisopropanolamine is also an organic reinforcing agent for cement concrete. As a cement grinding aid and concrete early strength agent, TIPA is generally considered to significantly increase the 28-day compressive strength of cement mortar.
- Explore on the synthesis of diethanol monoisopropanolamineAlcohol amines mainly include ethanolamine, isopropanolamine, etc., which are important basic chemical materials. The molecular structure of these substances contains alcohol and amine functional groups, and has the chemical properties of alcohols and amines, making them in many Synthetic applications have shown very useful coordination properties with the formation of a cool acid reaction, which reacts with hydrazine to form a guanamine-based compound. Because of their greater polarity, these molecules can be used as a raw material for surfactants, as well as fiber industrial refining agents, antistatic agents, dyeing auxiliaries and fiber wetting agents. It can also be used in the preparation of synthetic detergents, cosmetics, lubricating oils, cutting oils, plasticizers, emulsifiers, etc. At present, the most widely used surfactants and desulfurizers for the application of alcohol amines.
- Study on Synthesis and between Molecular Structure and Performance of Ether-type Polycarboxylate SuperplasticizerStudy on Synthesis and between Molecular Structure and Performance of Ether-type Polycarboxylate Superplasticizer The development and progress of concrete admixture technology has played a decisive role in the technological progress of the concrete industry. Throughout the industry, the entire industry has experienced the development of the first generation of ordinary water reducers represented by wood calcium and the second generation of superplasticizers represented by naphthalene series. As the third generation, the latest generation of high performance water reduction The agent, polycarboxylate high-performance water reducer has good performance in water reduction, moisture retention, plasticization, shrinkage and environmental protection, and has become the future development direction of the concrete admixture industry.
- Relationship between structure and properties of nonionic surfactantsRelationship between structure and properties of nonionic surfactants Nonionic surfactants are indispensable chemicals in people's daily life and industrial and agricultural production, and their application range is also expanding. In particular, nonionic surfactants are important in surfactants because of their convenient preparation, superior performance, compatibility with human body and environment, and their increasingly widespread use.
- How to better play the role of cement grinding aidHow to better play the role of cement grinding aid With the rapid development of China's cement industry and the country's high attention to energy conservation and emission reduction, cement grinding aids have become a must for cement enterprises, and also bring significant economic benefits to many cement companies. Correct selection and use of cement grinding aids suitable for the actual conditions and production conditions of the enterprise can not only greatly increase the output of cement platforms, improve the performance of cement, but also reduce the consumption of clinker and increase the amount of mixed materials. The use of resources to reduce emissions of carbon dioxide, nitrogen oxides, etc., to save energy and reduce environmental protection, improve economic and social benefits, and greatly enhance the competitiveness of cement companies in the market.