Polyethylene glycol (PEG) is a widely used polyether polymer compound. Polyethylene glycol (PEG) can be used in many fields such as medicine, health, food, and chemical industry. Polyethylene glycol (PEG) can be dissolved in water and many solvents, and the polymer has excellent biocompatibility, can be dissolved in the tissue fluid in the body, and can be quickly eliminated by the body without any toxic side effects.
Even more so, when polyethylene glycol (PEG) is coupled to other molecules, many of the superior properties of polyethylene glycol are transferred to the conjugate. Therefore, the medical application of polyethylene glycol has received extensive attention and has been recognized by the US Food and Drug Administration (FDA).
In the pharmaceutical industry, polyethylene glycol can be used as a pharmaceutical excipient to improve various properties of the drug, such as dispersibility, film formation, lubricity, sustained release, and the like. In the synthesis and modification of new biomaterials, polyethylene glycol as part of the material will impart new properties and functions to the material, such as hydrophilicity, flexibility, anticoagulant, and anti-macrophage phagocytosis.
In the application of polyethylene glycol, the end groups play a decisive role, and different end groups of polyethylene glycol have different uses. In practical applications, the polyethylene glycol polymer chain end is not limited to the terminal hydroxyl group, and other more reactive functional groups such as p-toluenesulfonate group, amino group, carboxyl group, aldehyde group, etc. can also be Introduced to both ends of the polyethylene glycol chain. The introduction of these functionalized groups expands the application range of polyethylene glycol, and it has broad application prospects in organic synthesis, peptide synthesis, polymer synthesis, sustained release and controlled release of drugs, and targeted application. Reports on synthesis and applications are increasing. Due to the presence of polyether, the copolymer has hydrophilicity and flexibility. Polyethylene glycol (PEG) can be used as a surfactant in the controlled release of drugs, and a microsphere surface modifier can also be used to prepare drug-loaded microspheres. Drug-loaded nanospheres, etc.